Last update
9/17/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 1 lozenge
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
50 mg
56%
Folate
667 mcg DFE (400 mcg folic acid)
167%
Vitamin B12 (as methylcobalamin)
3,000 mcg
125,000%
Top Medical Research Studies
7
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Read More
Most Useful Reviews
7.5
Improved workouts
5 people found this helpful
I improved my workouts significantly after discovering I was deficient in B-12 through muscle testing. I switched from a B complex supplement to methyl B-12, which my trainer recommended. Since then, my training sessions have enhanced; I've become stronger and increased my endurance. I also appear to burn more fat, possibly due to the enhanced muscle from the improved workouts. Furthermore, I experience less muscle pain upon waking now.
Read More
4
Excellent company
The company is superb for treating nerve pain. I find the quantity suitable, and the taste and aroma are quite pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved workouts
5 people found this helpful
I improved my workouts significantly after discovering I was deficient in B-12 through muscle testing. I switched from a B complex supplement to methyl B-12, which my trainer recommended. Since then, my training sessions have enhanced; I've become stronger and increased my endurance. I also appear to burn more fat, possibly due to the enhanced muscle from the improved workouts. Furthermore, I experience less muscle pain upon waking now.
Read More
4
Excellent company
The company is superb for treating nerve pain. I find the quantity suitable, and the taste and aroma are quite pleasant.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu Z, Chen Z, Wu Z, Tang M, Lin Y, et al. Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:973. 10.1186/s12891-024-08095-5
